NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Vinblastine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Cervical CarcinomaKB-3----results indicate a marked decrease in apoptosis and a delay in caspase-3 activation in response to vinblastine when c-Jun induction is blocked, implicating a proapoptotic role for c-Jun in this contex.18094076
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Cervical CarcinomaKB-3----Results suggest that vinblastineinduced c-Jun may down-regulate p21 only in cells that lack wild-type p53 function.18094076
JUNjun proto-oncogene3725Cervical CarcinomaKB-3----Vinblastine treatment in all cell lines examined causes a robust increase in c-Jun protein expression and phosphorylation and a corresponding increase in activator protein-1 (AP-1) transcriptional activity. We show in KB-3 carcinoma cells that this is due to a strong autoamplification loop involving the proximal AP-1 site in the c-Jun promoter, resulting in highly increased c-Jun mRNA and c-Jun protein.18094076

 






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