NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Tomatidine

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

cytochrome c oxidase subunit II

Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus

RAW264.7

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Tomatidine suppressed the COX-2 protein level in a dose-dependent manner

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus

RAW264.7

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In the presence of tomatidine at 10-40 µmol/L, the binding activity of NF-kappaB was suppressed in a dose-dependent manner.

nitric oxide synthase 2, inducible

Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus

RAW264.7

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The iNOS protein was barely detectable in unstimulated cells but markedly increased after LPS treatment, and tomatidine caused dose-dependent inhibition of LPS-induced iNOS expression.

prostaglandin E receptor 3 (subtype EP3)

Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virus

RAW264.7

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Tomatidine suppressed the PGE2 production.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.