NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Tiliroside

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Breast adenocarcinomaMCF-7>50 µM---Tiliroside more effective against topoisomerase II than topoisomrase I. It is possible that tiliroside induce conformational DNA changes and hinder the formation of enzyme-DNA cleavable complexes.It induces both apoptosis and necrosis in breast cancer MCF-7 cells.The apoptotic cell death was observed for Tiliroside (44-46%) in a concentration range of 10 to 100µM.18557426

 






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