NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Tetrandrine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Colon CancerHT-29----AKT inhibition and GSK3-Beta activation are involved in tetrandrine mediated changes of cell cycle or apoptosis regulatory proteins in HT-29 cells.18437054
AKT1v-akt murine thymoma viral oncogene homolog 1207Lung adenocarcinomaA549----Results suggest that Tetrandrine selectively inhibits the proliferation of lung cancer cells by blocking Akt activation.19255520
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerHT-29----Tetrandrine induced a decrease in procaspase 3 and an increase in cleaved, active caspase 3, and PARP was cleaved to its characteristic 85 kDa fragment, suggesting that tetrandrine caused caspase 3 activation and apoptosis.18437054
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Colon CancerHT-29----In HT-29 cells, the level of p27kip1 protein was significantly increased after tetrandrine treatmen.18437054
GSK3Bglycogen synthase kinase 3 beta2932Colon CancerHT-29----Inhibition of GSK3Beta effectively reversed G1 arrest and apoptosis induced by tetrandrin.18437054
MAPK1mitogen-activated protein kinase 15594Lung adenocarcinomaA549----Results suggest that Tetrandrine increases apoptosis by inhibiting ERK.19255520

 






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