NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Taxifolin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NQO1NAD(P)H dehydrogenase, quinone 11728Colon cancerHCT-116----Taxifolin induced a moderate increase in QR activity at a concentration range of 31.3 to 62.5 mM, while QR activity was decreased at higher concenrations (125—250 mM) due to cytotoxicity.It was cytotoxic to HCT116 cell lines, with an IC50 value of 63.42.The CD of taxifolin was 11.03 mM, leading to a CI value of 5.7.17541156
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-200±10 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-240±10 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415

 






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