NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Tannic acid

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581T cell leukemiaJurkat T----Tannic acid at 50 or 100µg/ml also induced Bax expression by 3- to 7-fold, cause apoptosis. TA-induced apoptotic cell death is also time- and concentration-dependent. Therefore, accumulation of Bax by tannic acid before apoptosis is consistent with the fact that Bax acts as a cell death promoter.11588135
ODC1ornithine decarboxylase 14953------Tannic acid pretreatments inhibit remarkably not only the induction of ODC activity produced by a single application of TPA but alsothe greater ODC responses elicited by each successive tumor promoter treatment.2032222
PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 95715T cell leukemiaJurkat T----Treatment of tannic acid at 50 µg/ml increased p27 levels by 2-fold at 4 h and by 3-fold at 12 and 24 h. And p27 acts as an inhibitor of the G1 to S phase transition .11588135

 






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