NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Tangeretin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 15243Colorectal AdenocarcinomaCaCo-2----They conclude that this methoxyflavone enhanced vinblastine uptake by specifically inhibiting drug efflux via P-gp. This may have potential as agent for reversing multidrug resistance or for recovering the bioavailability of certain drugs. The steady-state uptake of [3H]vinblastine was increased by tangeretin in a concentration-dependent manner, and the uptakes amounted to 906 ± 23.6% of the control, in the presence of 50µM methoxyflavones.10734174

 






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