NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Silvestrol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Breast CarcinomaMDA-MB-231----Levels of Bcl-2 diminished within the first 8 h of exposing MDA-MB-231 cells to silvestrol.19401772
birc5abaculoviral IAP repeat-containing 5a373110Breast CarcinomaMDA-MB-231----Levels of survivin and Mcl-1 decreased substantially after 48 .19401772
CCND1cyclin D1595Breast CarcinomaMDA-MB-231----Levels of cyclin D1 diminished within the first 8 h of exposing MDA-MB-231 cells to silvestrol.19401772
MCL1myeloid cell leukemia sequence 1 (BCL2-related)4170Breast CarcinomaMDA-MB-231----Levels of Mcl-1 decreased substantially after 48 .19401772
MYCv-myc myelocytomatosis viral oncogene4609Breast CarcinomaMDA-MB-231----Levels of c-myc diminished within the first 8 h of exposing MDA-MB-231 cells to silvestrol.19401772

 






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