NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Scopoletin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AHRaryl hydrocarbon receptor196------Scopoletin significantly reduced mRNA expression level of Ahr20619141
birc5abaculoviral IAP repeat-containing 5a373110------mRNA expression of survivin was downregulated significantly as revealed by statistical analysis20619141
CASP3caspase 3, apoptosis-related cysteine peptidase836------Western Blot analysis and mRNA quantification showed that scopoletin significantly elevated the Caspase-3 expression20619141
CCND1cyclin D1595------mRNA levels of Cyclin D1 was significantly elevated with the treatment of Scopoletin as compared to controlled group20619141
CYPIA1cytochrome P450, family 1, subfamily A, polypeptide 11543------Western Blot analysis and mRNA quantification showed that scopoletin significantly reduced the CYPIA1 overexpression.20619141
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313------The MMP-2 mRNAexpression was significantly blocked by scopoletin treatment20619141
MYCv-myc myelocytomatosis viral oncogene4609------mRNA levels of c-myc was significantly elevated with the treatment of Scopoletin as compared to controlled group20619141
PCNAproliferating cell nuclear antigen5111------From the westren bolt analysis and RT-PCR it was revealed that expression level of PCNA was significantly elevated after prolonged administration of DMBA on skin20619141
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)6774------Expression of Stat-3 from western blotting and the mRNA expression of Stat-3 were found to be significantly reduced with the doses of scopoletin as compared to control.20619141
TIMP2TIMP metallopeptidase inhibitor 27077------The TIMP-2 mRNAexpression was significantly elevated by scopoletin treatment20619141
TP53tumor protein p537157------The p-53 expression was significantly elevated in the scopoletin administered group.20619141

 






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