NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Sanguinarine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790LeukemiaU-937----sanguinarine completely blocked the activation of NF-kB induced by TNF, IL-1, phorbol ester, and OA but not that activated by H2O2 and ceramide.9374492
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790T cell leukemiaJurkat T----sanguinarine completely blocked the activation of NF-kB induced by TNF, IL-1, phorbol ester, and OA but not that activated by H2O2 and ceramide.9374492

 






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