NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Rotenone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CYP19A1cytochrome P450, family 19, subfamily A, polypeptide 11588Adrenocortical CarcinomaH295R0.3 µM---Rotenone (a flavonoid derivative) was by far the most potent aromatase inhibitor, with an IC50 value of about 0.3 µM.15319488
NDUFS1NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 4719Breast adenocarcinomaMCF-7----inhibition of NADH:ubiquinone oxidoreductase activity lowers the level of induced ODC activity leading to the antiproliferative effect and anticancer action.9520374

 






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