NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Rosmanol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Colon CancerCOLO-205----the expression of Bax decreased in cytosol and increased in mitochondria in a time-dependent manne.21112365
BIDBH3 interacting domain death agonist637Colon CancerCOLO-205----The engagement of Fas and Fas ligand (FasL) induces the activation of caspase-8, followed by the cleavage of a pro-apoptotic protein,Bid, to its truncated form, tBi.21112365
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerCOLO-205----the band of pro-caspase-3 protein after 24 h of 50 lM rosmanol treatment is less than that of the control group, indicating the cleavage of procaspase-3 to active caspase-3. Furthermore, the lower expression of cleaved caspase-3 at 24 h is likely due to degradation secondary to apoptosis. The result showed a gradual decrease in the levels of pro-caspase-9 and pro-caspase-3 and a corresponding increase in the cleavage of pro-caspase-9 and pro-caspase-3, indicating that both caspases were activated after rosmanol treatment.21112365
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerCOLO-205----the expression of both pro-caspase-8 and Bid decreased at 6 h after rosmanol treatment and the trend of reduction continued from 6 to 24 h.21112365
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon CancerCOLO-205----the band of pro-caspase-3 protein after 24 h of 50 lM rosmanol treatment is less than that of the control group, indicating the cleavage of procaspase-3 to active caspase-3. Furthermore, the lower expression of cleaved caspase-3 at 24 h is likely due to degradation secondary to apoptosis. The result showed a gradual decrease in the levels of pro-caspase-9 and pro-caspase-3 and a corresponding increase in the cleavage of pro-caspase-9 and pro-caspase-3, indicating that both caspases were activated after rosmanol treatment.21112365
FasTNF receptor superfamily, member 6355Colon CancerCOLO-205----The engagement of Fas and Fas ligand (FasL) induces the activation of caspase-8, followed by the cleavage of a pro-apoptotic protein,Bid, to its truncated form, tBi.21112365
FASLGFas ligand(TNF superfamily, member 6)356Colon CancerCOLO-205----The engagement of Fas and Fas ligand (FasL) induces the activation of caspase-8, followed by the cleavage of a pro-apoptotic protein,Bid, to its truncated form, tBi.21112365
PARP1poly (ADP-ribose) polymerase 1142Colon CancerCOLO-205----rosmanol induced dose- and time-dependent proteolytic cleavage of PARP, resulting in a reduction of the 116 kDa protein and an accumulation of the 85 kDa fragment.21112365

 






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