NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Rocaglamide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
IFNGinterferon, gamma3458T cell leukemiaJurkat T----In the presence of rocaglamide the production of IFN-gamma was suppressed in a dose-dependent manner. At a concentration of 50 nM, rocaglamides completely blocked T cell activation-induced expression of IFN-gamma.15905551
IL2 interleukin 23558T cell leukemiaJurkat T----In the presence of rocaglamide the production of IL-2 was suppressed in a dose-dependent manner. At a concentration of 50 nM,rocaglamide led to a 60-85% reduction in IL-.15905551
IL4interleukin 43565T cell leukemiaJurkat T----In the presence of rocaglamide the production of IL-4 was suppressed in a dose-dependent manner. At a concentration of 50 nM, rocaglamide completely blocked T cell activation-induced expression of IL-.15905551
JUNjun proto-oncogene3725T cell leukemiaJurkat T----Data indicate that rocaglamide may differentially impair c-Jun expression in activated T cells.15905551
NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 14772T cell leukemiaJurkat T----Data indicate that rocaglamide may differentially impair NF-AT expression in activated T cells.15905551
TNFtumor necrosis factor7124T cell leukemiaJurkat T----In the presence of rocaglamide the production of TNF-alpha was suppressed in a dose-dependent manner. At a concentration of 50 nM, rocaglamide led to a 60-85% reduction in TNF-alpha production.15905551

 






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