NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: pristimerin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----Electrophoretic mobility shift assay EMSA, demonstrated a markedly reduced binding activity of NF-kappaB in nuclear extracts of pristimerin-treated cells. These results suggest that pristimerin inhibits the induction of inducible NO synthase by a mechanism which involves inhibition of NF-kappaB activation.9384235

 






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