NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Pinocembrin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Colon cancerHCT-116----Pinocembrin (100 mµM) induced Bax translocation to mitochondria. Overexpression of Bax sensitized cells to pinocembrin-induced apoptosis as evidenced from MTT and chromatin condensation.17186548
BAXBCL2-associated X protein581Neuroblastoma SH-SY5Y----Pinocembrin treatment reduced the expression of Bax and had no effect on Bcl-2, thus decreased the Bax-Bcl-2 ratio.18625218

 






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