NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Perillyl Alcohol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
IGF2insulin-like growth factor 23481Liver tumor-----Testing of compound was performed in-vivo. By comparing the larger liver tumors from the Perillyl Alcohol-treated rats to those from untreated rats we could have introduced a bias against observing a relative increase in the expression of the M6PIIGFII and TGF-BETA type I, II, and III receptors.7867007
RAP1ARAP1A, member of RAS oncogene family5906LeukemiaK-562----Perillyl Alcohol was found to decrease the up-regulation of Rap1a induced by mevalonate depletion by 50-59%.12671036
RHOAras homolog family member A387LeukemiaK-562----Perillyl Alcohol (PA) concentrations of 0.5 mM yielded 33-39% decreases in RhoA protein levels.12671036
RHOBras homolog family member B388LeukemiaK-562----Perillyl Alcohol (0.5 mM) was found to decrease the up-regulation of RhoB induced by mevalonate depletion by 70%.12671036
TGFBR1transforming growth factor, beta receptor 17046Liver tumor-----By comparing the larger liver tumors from the Perillyl Alcohol-treated rats to those from untreated rats we could have introduced a bias against observing a relative increase in the expression of the M6PIIGFII and TGF-BETA type I, II, and III receptors.7867007
TGFBR2transforming growth factor, beta receptor 27048Liver tumor-----By comparing the larger liver tumors from the Perillyl Alcohol-treated rats to those from untreated rats we could have introduced a bias against observing a relative increase in the expression of the M6PIIGFII and TGF-BETA type I, II, and III receptors.7867007
TGFBR3transforming growth factor, beta receptor 37049Liver tumor-----By comparing the larger liver tumors from the Perillyl Alcohol-treated rats to those from untreated rats we could have introduced a bias against observing a relative increase in the expression of the M6PIIGFII and TGF-BETA type I, II, and III receptors.7867007

 






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