NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Panduratin A

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Epidermoid Nasopharyngeal CancerKB----MMP-9 protein and mRNA levels were significantly decreased after panduratin A treatment (p 0.05).19122290
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Lung adenocarcinomaA549----Treatment with an apoptosis-inducing concentration of panduratin A resulted in significant inhibition of Nuclear Factor-kappa Beta (NF-kappaB) translocation from cytoplasm to nuclei activated by tumor necrosis factor- alpha (TNF-alpha), as illustrated by the HCS assay.21441862
PLAUplasminogen activator, urokinase5328Epidermoid Nasopharyngeal CancerKB----It was found that uPA mRNA expression was downregulated by panduratin A. At 25 mM, panduratin A reduced uPA mRNA expression up to 37%.19122290

 






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