NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: paclitaxel

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MAPK1mitogen-activated protein kinase 15594Breast CarcinomaMDA-MB-435----Blocking the activity of p38 greatly reversed the stimulation of apoptosis by 4 nM paclitaxel, whereas, on the contrary, activating either kinase during paclitaxel treatment resulted in an increase of the effect of 0.5 nM paclitaxel on apoptosis. These results suggest that p38 PKA activation precede paclitaxel-dependent apoptosis and form part of its mechanism of action.12796407
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha5566Breast CarcinomaMDA-MB-435----PKA was stimulated in a dose-dependent manner by a range of paclitaxel concentrations similar to that which is stimulatory for apoptosi.12796407

 






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