NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Osthole

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

B-cell CLL/lymphoma 2

Lung adenocarcinoma

A549

-

-

-

-

Results indicated that Osthole up-regulation of the Bax/Bcl-2 ratio in a dose-dependent manner.

cyclin B1

Lung adenocarcinoma

A549

-

-

-

-

Western blotting analysis revealed that Osthole decreased the protein levels of Cyclin B1 via a dose-dependent manner.

cyclin-dependent kinase 1

Lung adenocarcinoma

A549

-

-

-

-

Western blotting analysis revealed that Osthole decreased the protein levels of p-Cdc2 via a dose-dependent manner.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.