NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Noscapine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon CancerLoVo----Noscapine effectively inhibited the proliferation of LoVo cells in vitro (IC50 = 75 lM). This cytotoxicity was reflected by cell cycle arrest at G2/M and subsequent apoptosis,as indicated by increased chromatin condensation and fragmentation, the upregulation of Bax and cytochrome c (Cyt-c), the downregulation of survivin and Bcl-2, and the activation of caspase-3 and caspase-9.22546556

 






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