NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Nimbolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP8caspase 8, apoptosis-related cysteine peptidase841Colon cancerHCT-116----Activation of caspase-8 suggests that nimbolide potentiated both extrinsic and intrinsic pathways of apoptosis.21078664
CASP8caspase 8, apoptosis-related cysteine peptidase841Cervix AdenocarcinomaHeLa----To investigate the effects of azadirachtin (135 µ M)and nimbolide (5 µ M) on the expression of markers associated with cell survival, proliferation and apoptosis, we analysed the mRNA and protein expression. Quantifi cation of each band by densitometric analysis revealed signifi cant increase in the expression of p53,p21, I k B, Bid, Bad, Bax, cytosolic cytochrome C,Apaf-1, caspase -2L, -6, -8, -9 and -3 and PARP cleavage.20429769

 






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