NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: nimbolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Cervix AdenocarcinomaHeLa----To investigate the effects of azadirachtin (135 µ M)and nimbolide (5 µ M) on the expression of markers associated with cell survival, proliferation and apoptosis, we analysed the mRNA and protein expression.Quantifi cation of each band by densitometric analysis revealed signifi cant. with decrease in the expression of cyclin D1,PCNA, NF- k B, p-I k B- a , IKK b , survivin, Bcl-2, Bcl-xL, Mcl-1 and mitochondrial cytochrome c in HeLa cells treated with azadirachtin and nimbolide compared to untreated control.20429769
BCL2B-cell CLL/lymphoma 2596Colon cancerHCT-116----We examined whether nimbolide can modulate the expression of these proteins. Our results revealed that nimbolide down-regulated the expression of Bcl-2,Bcl-xL, cIAP-1, cIAP-2, I-FLICE, survivin, and XIAP. The effect of nimbolide was most prominent at 5 and 10 M. Overall, these results suggest that nimbolide can down-regulate cell survival protein.21078664

 






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