NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Naringenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Gastric CancerAGS----Western blot results showed that expression level of Bax was increased in a dose-dependent manner.22194772
BCL2L1BCL2-like 1598Gastric CancerAGS----Western blot results showed that expression level of Bcl-xL was decreased in a dose-dependent manner.22194772
CASP3caspase 3, apoptosis-related cysteine peptidase836Gastric CancerAGS----Flavonoids caused downregulation of procaspase-3 which consequently increased the activity of caspase-3.22194772
CCNB1cyclin B1891Gastric CancerAGS----It reduces the protein level of cyclin B1 in a dose-dependent manner.Decrease of cyclin B1 expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
CDC25Ccell division cycle 25 homolog C (S. pombe)995Gastric CancerAGS----It reduces the protein level of cdc 25c in a dose-dependent manner.Decrease of cdc 25c expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
CDK1cyclin-dependent kinase 1983Gastric CancerAGS----It reduces the protein level of cdc 2 in a dose-dependent manner.Decrease of cdc 2 expression might be a molecular mechanism through which flavonoids induce G2/M arrest.22194772
COX-1cytochrome c oxidase subunit I4512Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7164.6 µM---It inhibits cyclooxygenase 1 (Cox-1) activity and it is an anti-inflammatory mechanism.Phytochemistry Reviews 1: 369-377, 2002
CYP19A1cytochrome P450, family 19, subfamily A, polypeptide 11588Breast adenocarcinomaMCF-72 µM---Naringenin inhibited aromatase activity with IC50 value of about 2µM.22209285
CYP19A1cytochrome P450, family 19, subfamily A, polypeptide 11588Adrenocortical CarcinomaH295R85 µM---The first inhibitory effects on aromatase activity in vitro in H295R cells were observed at concentrations above 10 mM for naringenin and above 1 mM for chrysin and apigenin.15319488
CYPIA1cytochrome P450, family 1, subfamily A, polypeptide 11543Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.70.2 µM---Naringenin potently inhibited Cyp1A activity with an IC50 of 0.2 µM. Cyp1A, which is e.g. involved in the activation of carcinogens from grilled meat, as a model phase 1 enzyme, and measured the potential of beer constituents to inhibit its enzymatic activity.Phytochemistry Reviews 1: 369-377, 2002
NOS2nitric oxide synthase 2, inducible4843Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.712.9 µM---Nitric oxide (NO) synthase (iNOS) and consequently, enhance the generation of NO. Generally, NO is an important signaling molecule, long-term elevated levels of NO, however, have been linked to early steps in carcinogenesis.It cause inhibition of lipopolysaccharide (LPS)-mediated induction of inducible nitric oxide synthase , which is an anti-inflammatory mechanis.Phytochemistry Reviews 1: 369-377, 2002
NQO1NAD(P)H dehydrogenase, quinone 11728Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7>50 µM---It induces the QR activity.Induction of phases 2 enzymes contributes to chemopreventive activity. QR is not catalyzing a conjugation reaction, but it is induced co-ordinately with other phase 2 enzymes and contributes to detoxification by reduction of reactive quinones to less reactive hydroquinones.Phytochemistry Reviews 1: 369-377, 2002
PARP1poly (ADP-ribose) polymerase 1142Gastric CancerAGS----During apoptosis, caspases induce PARP cleavage and inactivation and cleavage of PARP helps cellular disassembly and is a marker of cells undergoing apoptosis.22194772

 






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