NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Morusin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerHT-29----Increase in the active form of Caspase-3 was also observed at 12-72 h. PARP is a substrate of caspase-3 and Active caspase-3 can also catalyze DFF-45 and DFF-35. Cleavage of PARP and translocation of DFF-40 in nuclei indicate the activity of caspase-3 and also suggest the results of DNA fragmentation.18485277
CASP8caspase 8, apoptosis-related cysteine peptidase841Colon CancerHT-29----Morusin, activate caspase-8 to elevate mitochondrial tBid and Bax to permeabilize the outer mitochondrial membrane, allowing eflux of cytochrome c and Smac/DIABLO into cytosol.18485277
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon CancerHT-29----Morusin cause activation of caspase-9 at the 12h of treatmen.18485277
CHUKconserved helix-loop-helix ubiquitous kinase1147Colon CancerHT-29----Morusin significantly decreased the phosphorylation i.e.,50% decrease for IKK-alpha at 48 h and total protein expression i.e., 60% at 12h.18485277
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells3551Colon CancerHT-29----Morusin significantly decreased the phosphorylation i.e.,30% decrease for IKK-Beta at 24 h and total protein expression i.e., 40% at 12.18485277
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Colon CancerHT-29----Morusin dramatically decreased nuclear NF-kappaB p65 subunit at 12 h (more than 50% decrease) of treatment and reached the lowest level at 24-72 h (more then 90% decrease.18485277

 






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