NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Morin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
COX-2cytochrome c oxidase subunit II4513Hepatocellular Carcinoma-----During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2.Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of COX-2, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis.19539802
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)4313Hepatocellular Carcinoma-----Matrix metalloproteinase MMP-2 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-2 level was found to be increased in DEN-induced animals when compared to control. MMP-2 levels were down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis.19539802
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Hepatocellular Carcinoma-----Matrix metalloproteinase MMP-9 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-9 level was found to be increased in DEN-induced animals when compared to control. MMP-9 level was down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis.19539802
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)5970Hepatocellular Carcinoma-----During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2.Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of NF-kappaB-p65, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis.19539802
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-115±10 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415
TNFtumor necrosis factor7124TNF sensitive murine fibroblast cellsL929-120±8 µM--The effects of flavonoid on tumor necrosis factor-R(TNF)-induced cytotoxicity in murine fibroblast L-929 cells was studied. The magnitude of protection and potentiation by this flavonoid was concentration-dependent and these effects were not altered when the flavonoid was added as much as 2 h after TNF treatment.9287415

 






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