NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: matairesinol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Prostate CancerLNCaP----Treatment with MAT markedly decreased Akt activity,which has been implicated as a key signaling mechanism in the TRAIL resistance of LNCaP prostate cancer cell.19935713
CASP8caspase 8, apoptosis-related cysteine peptidase841Prostate CancerLNCaP----We also examined the protein levels of the major TRAIL-DISC proteins, c-FLIPL/S, caspase-8 and FADD after 5 and 20 h of MAT treatment. Interestingly, a clear decrease in protein levels of both c-FLIPL/S and caspase-8, but not of FADD, was observed after 20-h MAT treatment.19935713
CFLARCASP8 and FADD-like apoptosis regulator8837Prostate CancerLNCaP----We also examined the protein levels of the major TRAIL-DISC proteins, c-FLIPL/S, caspase-8 and FADD after 5 and 20 h of MAT treatment. Interestingly, a clear decrease in protein levels of both c-FLIPL/S and caspase-8, but not of FADD, was observed after 20-h MAT treatment.19935713

 






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