NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: mahanine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Human promyelocytic leukemiaHL-60----mahanine treatment resulted in time dependent increase in the proteolytic activity of various caspases in HL-60 cells by comparing the activity of each caspases in the control cells. A significant increase in the activity of caspase-3 was observed since 8 hr of mahanine treatment.14667927
CASP6caspase 6, apoptosis-related cysteine peptidase 839Human promyelocytic leukemiaHL-60----mahanine treatment resulted in time dependent increase in the proteolytic activity of various caspases in HL-60 cells by comparing the activity of each caspases in the control cells. A significant increase in the activity of caspase-6 was observed since 8 hr of mahanine treatment.14667927
CASP8caspase 8, apoptosis-related cysteine peptidase841Human promyelocytic leukemiaHL-60----mahanine treatment resulted in time dependent increase in the proteolytic activity of various caspases in HL-60 cells by comparing the activity of each caspases in the control cells. Activity of caspase-8 slowly increased until 12 hr of mahanine treatment.t.14667927
CASP9caspase 9, apoptosis-related cysteine peptidase842Human promyelocytic leukemiaHL-60----mahanine treatment resulted in time dependent increase in the proteolytic activity of various caspases in HL-60 cells by comparing the activity of each caspases in the control cells. Activity of caspase-9 slowly increased until 12 hr of mahanine treatment.t.14667927
PARP1poly (ADP-ribose) polymerase 1142Human promyelocytic leukemiaHL-60----Cleavage of PARP in HL-60 cells started at 4 hr after treatment with mahanine (10 mM) and became clearer when caspase-3 activation increased significantly.14667927

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.