NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Macranthoside B

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581HepatomaHep G2----Densitometric analysis revealed that the expression of Bax protein was increased by 82% and 113% in those cells treated with 30 and 40 µM MB, respectively.19406196
BCL2B-cell CLL/lymphoma 2596HepatomaHep G2----The expression of Bax protein was dramatically increased, while the protein level of Bcl-2 was slightly decreased.19406196
CASP3caspase 3, apoptosis-related cysteine peptidase836HepatomaHep G2----Although the expression of Procaspase-3 decreased slightly, the protein level of Caspase-3, p17 and p12 subunits increased, indicating the activation of Caspase-3.19406196
CASP9caspase 9, apoptosis-related cysteine peptidase842HepatomaHep G2----After HepG2 cells were treated with MB for 4 h, the expression of Procaspase-9 decreased significantly.19406196
PARP1poly (ADP-ribose) polymerase 1142HepatomaHep G2----With the increasing concentration of MB, the expression of cleaved PARP increased, confirming that apoptosis induction of MB was involved in its anti-tumor effec.19406196

 






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