NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Liquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TP53tumor protein p537157Hepatocellular carcinomaSMMC-7721----0.4 mM liquiritigenin induced a significant increase in the expression of p53. The level of p53 increased significantly when SMMC7721cells were treated with 0.4 mM liquiritigenin for 12 h, and remained elevated until 72 h.Densitometric analysis showed the increases in the ratio of p53/b-actin band densities reached statistical significance at 48 h(2.0-fold, p < 0.05) and 72 h (2.4-fold, p < 0.01).19150383

 






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