NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Liquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Hepatocellular carcinomaSMMC-7721----Caspase-3 plays a central role in mediating various apoptotic responses. In this study, caspase-3 protease activity significantly increased in a time-dependent manner after liquiritigenin treatment. 0.4 mM liquiritigenin strongly induced activation of caspae-3 protease as early as 24 h, and the maximum activity at 72 h was 773.94 ± 31.04%, which was about 7-fold increase compared with control.19150383
CASP3caspase 3, apoptosis-related cysteine peptidase836Liver CancerHUH7----Compound showed at least a 50%increase in caspase activity showing the ability of these flavonoids to induce apoptosis in HuH-7 cells21495101

 






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