NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Licochalcone A

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

MDM2

Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)

4193

Gastric Cancer

AGS

-

-

-

-

Licochalcone A inhibited the expression of matrix metalloproteinase-9 in the liver. And MMP-9 has known role in colon cancer metastasis.

21216524

MDM2

Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)

4193

Gastric Cancer

MKN-28

-

-

-

-

MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.

21216524

MDM2

Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)

4193

Gastric Cancer

MKN-45

-

-

-

-

MDM2 also play essential roles in the regulation of cell cycle. Licochalcone A treatment resulted in a dose-dependent decrease in MDM2 protein levels, suggesting that Licochalcone A may induce cell cycle arrest by affecting the levels of MDM2 in gastric cancer cells.

21216524

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.