NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Isoliquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
TIMP2TIMP metallopeptidase inhibitor 27077Prostate CancerDU-145----Secretion of TIMP-2 was not affected by EGF but increased by ISL treatment regardless of EGF treatment. TIMP-2 preferntially inhibits MMP-2. Both activation and activity of MMP-2 depend on TIMP-2, which plays a dual role in MMP-2 activation. ISL increased TIMP-2 secretion, which probably contributed to the decreased invasion and migration of DU145 cell.18824345

 






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