NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Isoliquiritigenin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
JUNjun proto-oncogene3725Prostate CancerDU-145----Isoliquiritigenin inhibited both basal and EGF-induced AP-1 DNA binding activity.18824345
JUNjun proto-oncogene3725Prostate CancerDU-145----Western blot analyses revealed that treating DU145 cells with EGF led to increased phosphorylation of c-Jun. ISL inhibited phosphorylation ofc-Jun. Treating cells with 10 µmol/L SP600125 led to a significant decrease in phosphorylation of c-Jun.18824345

 






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