NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Honokiol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Prostate CancerLNCaP----After honokiol treatment, we observed activated caspases 3 as exhibited by increased intensity of protein bands at 17 kDa.17326044
CASP8caspase 8, apoptosis-related cysteine peptidase841Prostate CancerLNCaP----After honokiol treatment, we observed activated caspases 8 as exhibited by increased intensity of protein bands at 40 kDa.17326044
CASP9caspase 9, apoptosis-related cysteine peptidase842Prostate CancerLNCaP----After honokiol treatment, we observed activated caspases 9, as exhibited by increased intensity of protein bands at 35 kDa.17326044
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790------Honokiol also suppressed PMA-induced NF-nB activation in ICR mice skin in vivo.16966432
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerLNCaP----After honokiol treatment, increased cleavage of PARP in a dose- and time-dependent manner was observed.17326044

 






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