NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: guggulsterone

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

CDK6

cyclin-dependent kinase 6

1021

head and neck squamous cell carcinoma

UM-22b

-

-

-

-

In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone

19762335

CDK6

cyclin-dependent kinase 6

1021

head and neck squamous cell carcinoma

UM-22b

-

-

-

-

In UM-22b cells, expression levels of proteins that promote the transition from the G1 to the S phase of the cell cycle, including CDK4, CDK6, CDK2, phosphorylated Rb, cyclin E and cyclin D1,which is a target gene for both STAT3 and NFkappaB, showed modest decreases following 16 h of guggulsterone

19762335

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.