NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Glossogin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BADBCL2-associated agonist of cell death572Lung adenocarcinomaA549----When the glossogin concentration was increased, the expression of the Bad protein increased, and helps in apoptosis.18976690
BAXBCL2-associated X protein581Lung adenocarcinomaA549----It was observed that, on increasing the glossogin concentration, the expressions of Bcax proteins decreased, which cause apoptosis.18976690
BCL2B-cell CLL/lymphoma 2596Lung adenocarcinomaA549----It was observed that, on increasing the glossogin concentration, the expressions of Bcl-2 proteins decreased, which cause apoptosis.18976690
BCL2L1BCL2-like 1598Lung adenocarcinomaA549----It was observed that, on increasing the glossogin concentration, the expressions of Bcl-xL proteins decreased, which cause apoptosis.18976690
CASP3caspase 3, apoptosis-related cysteine peptidase836Lung adenocarcinomaA549----The results shown, glossogin-induced activation of caspase-3 was observed after 24 h of glossogin treatment, helps in apoptosis. Both caspases were activated dose dependently by glossogin, and the activity level differed only slightly between caspase-3 and-9 .18976690
CASP9caspase 9, apoptosis-related cysteine peptidase842Lung adenocarcinomaA549----The results shown, glossogin-induced activation of caspase-9 was observed after 24 h of glossogin treatment, helps in apoptosis.Both caspases were activated dose dependently by glossogin, and the activity level differed only slightly between caspase-3 and-9 .18976690
CYCScytochrome c54205Lung adenocarcinomaA549----On increasing concentration of glossgin, more cytochrome C released from mitochondria to cytosol and the expression of procaspase-3 protein declined. Cytochrome C in cytosol stimulated cell and cleaved procaspase-9 to active type caspase-9. Expression of the procaspase-3 protein decreased and caspase-3 was activated, implying that caspase-9 activated procaspase-3 to cleave and form the active-type caspase-3.18976690

 






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