NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Glabridin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)6714Breast CarcinomaMDA-MB-231----They found that glabridin decreased the phosphorylation of FAK at 397, 576 and 925, and increased inactive phosphorylation Src at Tyr 527. The association of FAK and Src increased in a time-dependent manner in glabridin-treated MDA-MB-231 cells, as detected by immunoprecipitation assay. Glabridin also caused that release of Src from FAK, resulting in the inactivation of FAK/Src complex.20626003

 






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