NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ginkgetin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Ovarian adenocarcinomaOVCAR-3----A decrease in pro-caspase-3 was clearly observed 12 h after the addition of ginkgetin (3 µg/ml), indicating the activation of this protease.such activation could still be detected 30 h post drug treatment. Here, the apoptosis induced by a high concentration of ginkgetin is mediated mainly by caspase(s) activated by H2O2 generated possibly through autooxidation of this biflavone.10935537

 






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