NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Genistein

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

CASP3

caspase 3, apoptosis-related cysteine peptidase

836

Liver Cancer

HUH7

-

-

-

-

Compound showed at least a 50%increase in caspase activity showing the ability of these flavonoids to induce apoptosis in HuH-7 cells

21495101

CASP3

caspase 3, apoptosis-related cysteine peptidase

836

Breast Carcinoma

Hs578T

-

-

-

-

It induced cell apoptosis through a caspase-3-dependent pathway and mediated cell cycle arrest in the G2/M phase. The induction of apoptosis in the breast cancer cell lines by genistein isoflavone confirmed by detection of increased caspase-3 activity in the isoflavone-treated HS578T and MDA-MB-231 cells.

19013426

CASP3

caspase 3, apoptosis-related cysteine peptidase

836

Breast Carcinoma

MDA-MB-231

-

-

-

-

It induced cell apoptosis through a caspase-3-dependent pathway and mediated cell cycle arrest in the G2/M phase. The induction of apoptosis in the breast cancer cell lines by genistein isoflavone confirmed by detection of increased caspase-3 activity in the isoflavone-treated HS578T and MDA-MB-231 cells.

19013426

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.