NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Farnesol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ATF3activating transcription factor 3467Lung CancerH-460----Analysis showed that FOH induced the expression of a great number of genes typically associated with ER stress response signaling, including ATF3.17699800
CASP3caspase 3, apoptosis-related cysteine peptidase836Lung CancerH-460----Examination of caspase activation in FOH-treated H460 cells showed that caspase-3 was significantly activated at 4 h, similar to the time course of poly(ADP-ribose) polymerase (PARP) cleavage.17699800
CASP9caspase 9, apoptosis-related cysteine peptidase842Lung CancerH-460----Examination of caspase activation in FOH-treated H460 cells showed that caspase-9 were significantly activated at 4 h, similar to the time course of poly(ADP-ribose) polymerase (PARP) cleavage.17699800
EGR1early growth response 11958Lung CancerH-460----FOH also induces the expression of several members of the Egr family, transcription factors that are important regulators of apoptosis and cell proliferation including Egr1.17699800
FOSFBJ murine osteosarcoma viral oncogene homolog2353Lung CancerH-460----The expression of several members of the Fos were also greatly upregulated witht the FOH treatment.17699800
JUNjun proto-oncogene3725Lung CancerH-460----The expression of several members of the Jun were also greatly upregulated witht the FOH treatment.17699800
MAPK1mitogen-activated protein kinase 15594Lung CancerH-460----Treatment of H460 cells with FOH induced the level of phosphorylated ERK, p38, and JNK.17699800
MAPK1mitogen-activated protein kinase 15594Lung CancerH-460----Treatment of H460 cells with FOH induced the level of phosphorylated ERK, p38, and JNK.17699800
MAPK8mitogen-activated protein kinase 85599Lung CancerH-460----Treatment of H460 cells with FOH induced the level of phosphorylated ERK, p38, and JNK.17699800

 






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