NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ent-7-alpha,14-beta-dihydroxykaur-16-en-15-one

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----The study showed that this entkauranoid inhibited LPS-induced NF- B activation in murine macrophage RAW264.7 cells at IC50 values between 0.07 and 0.42 íM.14510600
NOS2nitric oxide synthase 2, inducible4843Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----The study showed that This entkauranoid markedly reduced LPS-induced NO production in a comparable concentration-dependent manne.14510600

 






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