NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Curcumin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerLNCaP----Curcumin completely suppressed TNF induced NF-kB activation in a dose-dependent manner, with maximum suppression occurring at around 25 µM.11753638
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerDU-145----Curcumin completely suppressed TNF induced NF-kB activation in a dose-dependent manner, with maximum suppression occurring at around 75 µM.11753638
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerLNCaP----Results demonstrate that LNCaP cells express constitutively active NF-nB, which is inhibited by curcumin.15252141
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Human promyelocytic leukemiaHL-60----TPA-induced NF-kappaB activation was significantly inhibited when the HL-60 cells were pretreated with 5 µM or 10 µM curcumin, while no significant effect was observed at 1 µM.12297018
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerPC-3----Transcriptional activitie of NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin12239622
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerLNCaP----Transcriptional activities of AP-1 and NF-kB were significantly decreased by the treatment with maximum non-toxic doses of curcumin12239622

 






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