NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Curcumin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

dual specificity phosphatase 10

Prostrate Carcinoma

LAPC-4

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-

-

-

Prostrate cancer cell line LAPC-4 retain the ability to up-regulate MKP5 in response to curcumin.

dual specificity phosphatase 10

Prostate Cancer

LNCaP

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-

-

-

Prostrate cancer cell line LNCaP retain the ability to up-regulate MKP5 in response to curcumin.

dual specificity phosphatase 10

Prostate Cancer

DU-145

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-

-

-

Prostrate cancer cell lines DU 145, retain the ability to up-regulate MKP5 in response to curcumin and that curcumin reduced p38-mediated, but not NFkB-mediated, pro-inflammatory signaling by T+1 in DU 145 cell.

dual specificity phosphatase 10

Prostate Cancer

PC-3

-

-

-

-

Prostrate cancer cell lines PC-3 retain the ability to up-regulate MKP5 in response to curcumin.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.