NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Cucurbitacin D

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596-Hut102----activated NF-kB was inhibited by cucurbitacin D in the nucleus, which resulted in accumulation of NF-kB in the cytoplasm, leading to down-regulation of the expression of antiapoptotic protein Bcl-221656752
BCL2L1BCL2-like 1598-Hut102----activated NF-kB was inhibited by cucurbitacin D in the nucleus, which resulted in accumulation of NF-kB in the cytoplasm, leading to down-regulation of the expression of antiapoptotic protein Bcl-xL.21656752
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790-Hut102----activated NF-kB was inhibited by cucurbitacin D in the nucleus, which resulted in accumulation of NF-kB in the cytoplasm.21656752

 






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