NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: cnicin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BECN1beclin 1, autophagy related8678MyelomaNCI-H929----Cnicin-induced upregulation of beclin-1 in NCI-H929 suggests that autophagy contributes to the observed effects.22205266
CASP3caspase 3, apoptosis-related cysteine peptidase836MyelomaNCI-H929----Caspase activation by cnicin was confirmed by immunoblot, predominantly revealing downregulation of full-length caspase 3 and concomitant appearance of cleaved caspases 3.22205266
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790MyelomaNCI-H929----Constitutive NF-kappaB activation as well as TNF-alpha-induced upregulation was blocked by cnicin.22205266
PIM2pim-2 oncogene11040MyelomaNCI-H929----cnicin preferentially kills lymphatic cells (predominantly B-cell derived) and hits myeloma cells at several known pathways and also on a novel one, survival kinase Pim-2, each potentially lethal.22205266

 






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