NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Cinnamaldehyde

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581HepatomaHep G2----Results displayed that pre-incubation the Hep G2 cells with 30 µM PFTalpha alone and 30 µM PFTalpha + 30µM Cin effectively inhibited the expression of Bax, p53 and CD95, as well as the cleavage of PARP.These pretreatment also prevented the downregulation of Bcl-XL in cells.20038571
BCL2L1BCL2-like 1598HepatomaHep G2----Results displayed that pre-incubation the Hep G2 cells with 30 µM PFTalpha alone and 30 µM PFTalpha + 30µM Cin effectively inhibited the expression of Bax, p53 and CD95, as well as the cleavage of PARP.These pretreatment also prevented the downregulation of Bcl-XL in cells.20038571
FASFas (TNF receptor superfamily, member 6)355HepatomaHep G2----Results showed that compound caused a time dependent increase in the CD95 (APO-1) protein expression in HepG2 cell.20038571
PARP1poly (ADP-ribose) polymerase 1142HepatomaHep G2----PARP cleavage was determined by immunoblotting analysis. Results showed that PARP proform (molecular mass, 116 kDa) was cleaved to give an 85kDa fragment in Cin-treated cells at 12 and 24h after treatmen.20038571
TP53tumor protein p537157HepatomaHep G2----Compound did cause an increase in the level of p53 as Hep G2 cells contain wild-type p5.20038571

 






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