NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Chrysophanol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
APAF1apoptotic peptidase activating factor 1317Liver CarcinomaJ5----Chrysophanol decreased protein levels of Apaf-1 in cancer cells.20169580
BAXBCL2-associated X protein581Liver CarcinomaJ5----Chrysophanol promoted levels of Bax.20169580
CASP12caspase 12100506742Liver CarcinomaJ5----Chrysophanol decreased protein levels of Caspase-12 in cancer cells.20169580
CASP3caspase 3, apoptosis-related cysteine peptidase836Liver CarcinomaJ5----Chrysophanol decreased protein levels of Caspase-3 in cancer cells.20169580
CASP8caspase 8, apoptosis-related cysteine peptidase841Liver CarcinomaJ5----Chrysophanol decreased protein levels of Caspase-8 in cancer cells.20169580
CASP9caspase 9, apoptosis-related cysteine peptidase842Liver CarcinomaJ5----Chrysophanol decreased protein levels of Caspase-9 in cancer cells.20169580
CYCScytochrome c54205Liver CarcinomaJ5----Chrysophanol promoted levels of Cytochrome c.20169580
ENDOGendonuclease G2021Liver CarcinomaJ5----Chrysophanol decreased protein levels of Endo G in cancer cells.20169580
GSTM1glutathione S-transferase mu 12944Liver CarcinomaJ5----Chrysophanol promoted levels of GST.20169580
LDHBlactate dehydrogenase B 3945Liver CarcinomaJ5----Chrysophanol promoted LDH activity about 377-516% (p<0.01 and p<0.001) in cancer cells.20169580

 






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