NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Chamaecypanone C

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Epidermoid Nasopharyngeal CancerKB----Incubation of KB cells with Chamaecypanone C for 24 h resulted in the activation of caspase 3 in a concentration-dependent manner20034474
CASP8caspase 8, apoptosis-related cysteine peptidase841Epidermoid Nasopharyngeal CancerKB----Results indicated that Chamaecypanone C induces apoptosis through activation of caspase 820034474
CCNB1cyclin B1891Epidermoid Nasopharyngeal CancerKB----Chamaecypanone C induced the expression of cyclin B1 in cells in a concentration-dependent manner20034474
CDC25Ccell division cycle 25 homolog C (S. pombe)995Epidermoid Nasopharyngeal CancerKB----up-shifting of the Cdc25 band was shown in the Chamaecypanone C-treated cells. These results indicated that Chamaecypanone C induced Cdc25C phosphorylation in cells.20034474
FOXM1forkhead box M12305Epidermoid Nasopharyngeal CancerKB----The levels of MPM-2 phosphoepitopes were increased in cells treated with Chamaecypanone C for 24 h, as shown bywestern blotting20034474
PARP1poly (ADP-ribose) polymerase 1142Epidermoid Nasopharyngeal CancerKB----Western blot analysis revealed that Chamaecypanone C induced the cleavage of PARP (116 kDa) into an 85 kDa C-terminal fragment in cells in a concentration-dependent manner.20034474
TUBG1tubulin7283Epidermoid Nasopharyngeal CancerKB----Result indicated that Chamaecypanone C inhibits microtubule assembly through binding to the colchicine-binding site of tubulin.20034474

 






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