NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Celastrol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792T cell leukemiaJurkat T----results indicate that celastrol prevents the diverse stimuli-induced I kB a degradation through inhibiting Ik Ba phosphorylation, thereby interfering with one of the common steps in the signaling cascade leading to the NF- kB activation.16984800

 






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