NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Butylated hydroxyanisole

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Cervix AdenocarcinomaHeLa----The level of anti-apoptotic protein Bcl-2 was clearly decreased by treatment with 100-300 µM Butylated hydroxyanisole.21113647
CASP3caspase 3, apoptosis-related cysteine peptidase836Cervix AdenocarcinomaHeLa----When the activities of caspase-3 was assessed in 150 µM Butylated hydroxyanisole-treated HeLa cells, caspase-3 activity was significantly increased and caspase-8 activity was slightly increased. Western blotting showed that the level of procaspase-3 was down-regulated in Butylated hydroxyanisole-treated HeLa cells and the intact form of PARP was decreased in these cells.21113647
CASP8caspase 8, apoptosis-related cysteine peptidase841Cervix AdenocarcinomaHeLa----When the activities of caspase-8 was assessed in 150 µM Butylated hydroxyanisole-treated HeLa cells, caspase-8 activity was slightly increased.21113647

 






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